Key result
The ACE D allele was significantly associated with a 2-fold increased risk of Henoch-Schönlein purpura compared to the I allele (OR 2.05), while the AGT M235T polymorphism showed no significant association.
Why the study?
Are ACE I/D and AGT M235T polymorphisms associated with Henoch-Schönlein purpura susceptibility in a Turkish population?
Case-Control (n=226)
No
Are ACE I/D and AGT M235T polymorphisms associated with Henoch-Schönlein purpura susceptibility in a Turkish population?
Odds Ratio: 2.0528 (95% CI 1.3632–3.0912)
Absolute Event Rate: 64.7% vs 47.2%
p-value: p=0.001
The ACE I/D polymorphism, specifically the D allele and ID+DD genotypes, is significantly associated with increased susceptibility to Henoch-Schönlein purpura in a Turkish population.
ACE D allele was associated with HSP susceptibility in this Turkish cohort; hypothesis-generating and requires validation before any clinical application.
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Nalbantoğlu et al. (2013) conducted a case-control in Henoch-Schönlein purpura (n=226). ACE I/D polymorphism (D allele) vs. ACE I/D polymorphism (I allele) was evaluated on Susceptibility to Henoch-Schönlein purpura (D vs. I allele frequency) (OR 2.0528, 95% CI 1.3632-3.0912, p=0.001). The ACE D allele was significantly associated with a 2-fold increased risk of Henoch-Schönlein purpura compared to the I allele (OR 2.05), while the AGT M235T polymorphism showed no significant association.
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