Key result
Women with endometriosis had significantly higher mean levels of MMP-2 in serum (6.03 vs 1.49 ng/ml) and peritoneal fluid (1.98 vs 0.61 ng/ml) compared to controls.
Why the study?
Are serum and peritoneal fluid levels of MMP-2 associated with the presence and stage of endometriosis?
Cross-Sectional (n=50)
Yes
Are serum and peritoneal fluid levels of MMP-2 associated with the presence and stage of endometriosis?
Absolute Event Rate: 6.03% vs 1.49%
p-value: p=0.000
MMP-2 levels in serum and peritoneal fluid are elevated in patients with endometriosis and correlate with disease stage, suggesting a potential role as a biomarker.
Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher the value of MMP-2 serum andperitoneal fluid, the higher the stage of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 104-109]
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Baharuddin et al. (2018) conducted a cross-sectional in Endometriosis (n=50). Endometriosis vs. Without endometriosis was evaluated on Serum MMP-2 level (ng/ml) (p=0.000). Women with endometriosis had significantly higher mean levels of MMP-2 in serum (6.03 vs 1.49 ng/ml) and peritoneal fluid (1.98 vs 0.61 ng/ml) compared to controls.
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