Key result
Elevated superoxide dismutase linked to ~24% higher odds of severe mitral stenosis.
Why the study?
The study examined whether the severity of mitral valve stenosis is associated with blood oxidative stress markers and other hematological and clinicodemographic parameters.
Cross-Sectional (n=75)
No
The severity of mitral valve stenosis is independently associated with elevated blood oxidative stress markers and inflammation-related cells.
No immediate change to mitral stenosis management; hypothesis-generating for oxidative stress role and requires prospective validation.
BACKGROUND: This study examined whether the severity of mitral valve stenosis (MVS) is associated with oxidative stress (OS) markers in the blood, and other hematological and clinicodemographic parameters. METHODS AND Various OS markers and laboratory parameters were determined in venous blood samples. For predictive analyses, 2 different analyses were performed to detect patients with severe MVS and those with moderate or severe (moderate/severe) MVS. Age (P=0.388) and sex (P=0.372) distribution were similar in the 3 groups. Multiple logistic regression analysis revealed that a high white blood cell (WBC) count (P=0.023) and high malondialdehyde (P=0.010), superoxide dismutase (SOD; P=0.008), and advanced oxidation protein products (AOPP; P=0.007) levels were independently associated with severe MVS. A low platelet count (P=0.030) and high malondialdehyde (P=0.018), SOD (P=0.008), and AOPP (P=0.001) levels were independently associated with having moderate/severe MVS. The best discriminatory factors for severe MVS were SOD (cut-off >315.5 ng/mL) and glutathione (cut-off >4.7 μmol/L). CONCLUSIONS: MVS severity seems to be affected by oxidant markers (malondialdehyde and AOPP), antioxidant enzymes (SOD), and inflammation-related cells (WBC and platelets). Future studies are needed to examine these relationships in larger populations.
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Düz et al. (2023) conducted a cross-sectional in Mitral valve stenosis (n=75). Oxidative stress markers (SOD, MDA, AOPP) vs. Mild or moderate mitral valve stenosis was evaluated on Independent association of superoxide dismutase (SOD) with severe mitral valve stenosis (OR 1.242, 95% CI 1.059-1.456, p=0.008). High blood levels of superoxide dismutase (OR 1.242), malondialdehyde, advanced oxidation protein products, and white blood cells were independently associated with severe mitral valve stenosis.
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