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March 9, 2016Drug Testing and Analysis

In vitro assessment of 24 CYP2D6 allelic isoforms on the metabolism of methadone

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Authors

YSYing SuJilin Academy of Agricultural SciencesYZYunyun ZhanNingbo UniversityBWBenfu WangHarbin Institute of Technology

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Su et al. (2016) studied this question.

synapsesocial.com/papers/6ab729fcab05c73df1a6eb46https://doi.org/10.1002/dta.1959
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stereoselective metabolism of methadone N‐demethylation by cytochrome P4502B6 and 2C192003 · 227 citations
  2. 2Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.1993 · 100 citations
  3. 3Methadone <i>N</i>‐demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A41999 · 180 citations
  4. 4Stereo-Selective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation2010 · 97 citations
  5. 5Pharmacogenetics and Anesthesiologists2005 · 41 citations