Statistical observations of the epoch of reionization (EOR) power spectrum provide a rich data set for understanding the transition from the cosmic "dark ages" to the ionized universe we see today. EOR observations have become an active area of experimental cosmology, and three first-generation observatories—MWA, PAST, and LOFAR—are currently under development. In this paper we provide the first quantitative calculation of the three-dimensional power spectrum sensitivity, incorporating the design parameters of a planned array. This calculation is then used to explore the constraints these first-generation observations can place on the EOR power spectrum. The results demonstrate the potential for upcoming power spectrum observations to constrain theories of structure formation and reionization.
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