Key result
Recombinant human IL-10 dose-dependently suppresses monocyte tissue factor expression and thrombin generation.
Why the study?
Monocytes and factor Xa are procoagulant agents involved in atherosclerosis and thrombosis, and the anticoagulant effect of IL-10 on FXa-activated human monocytes was evaluated.
IL-10 exhibits anticoagulant effects by inhibiting tissue factor expression and thrombin generation in factor Xa-activated human monocytes, illustrating cross-talk between inflammation and coagulation.
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IL-10 may dampen FXa-induced monocyte procoagulability in vitro; leaves open any role in atherothrombosis and requires clinical translation studies.
Ben-Hadj-Khalifa et al. (2012) studied Atherosclerosis and thrombosis. Recombined human IL-10 was evaluated on Tissue factor (TF) mRNA and protein synthesis, and TF-dependent thrombin generation. Recombined human IL-10 inhibited both tissue factor mRNA and protein expression in a dose-dependant manner, and significantly inhibited all phases of human monocyte-triggered thrombin generation.
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