Key result
Alcoholic liver cirrhosis was associated with lower specific insulin binding to circulating monocytes compared to control subjects (p < 0.005).
Case-Control (n=11)
Patients with alcoholic liver cirrhosis exhibit decreased insulin receptor concentration on circulating monocytes, likely secondary to chronic hyperinsulinemia.
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May suggest insulin resistance in alcoholic cirrhosis; leaves open clinical relevance of monocyte assays.
Hyperinsulinemia and insulin resistance have been reported in patients with liver cirrhosis. Since insulin receptor decrease has been demonstrated in some conditions of insulin resistance, we have studied insulin binding to circulating monocytes in eleven patients with alcoholic liver cirrhosis. Specific insulin binding at tracer concentration was lower in cirrhotics than in control subjects (p < 0.005). Insulin binding to monocytes was correlated with basal plasma insulin level in cirrhotics (r = -0.76; p < 0.01). The inhibiting effect of native insulin on 125I-insulin binding was similar in cirrhotics and controls suggesting that concentration rather than affinity of the binding sites is affected in cirrhosis of the liver. These findings suggest that decrease in insulin receptor concentration exists in liver cirrhosis, probably as a consequence of chronic hyperinsulinemia.
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Greco et al. (1980) conducted a case-control in Alcoholic liver cirrhosis (n=11). Alcoholic liver cirrhosis vs. Control subjects was evaluated on Specific insulin binding at tracer concentration to circulating monocytes (p=<0.005). Alcoholic liver cirrhosis was associated with lower specific insulin binding to circulating monocytes compared to control subjects (p < 0.005).
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