Key result
Nebulized ketamine at doses of 1 mg/kg and 1.5 mg/kg significantly increased the proportion of patients with no post-operative sore throat at 0 hours compared to 0.5 mg/kg (77.8% and 85.2% vs 37.0%, p<0.001).
RCT (n=81)
Double-blind
Computer generated closed envelope technique
No
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May support 1–1.5 mg/kg nebulized ketamine to reduce early post-operative sore throat; leaves open confirmation in larger randomized trials.
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Reddy et al. (2017) conducted an RCT in Post-operative sore throat due to tracheal intubation (n=81). Ketamine nebulization vs. 0.5 mg/kg ketamine nebulization was evaluated on Incidence of no post-operative sore throat at 0 hours (p=<0.001). Nebulized ketamine at doses of 1 mg/kg and 1.5 mg/kg significantly increased the proportion of patients with no post-operative sore throat at 0 hours compared to 0.5 mg/kg (77.8% and 85.2% vs 37.0%, p<0.001).
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