Key result
Propofol co-induction with either ketamine or midazolam provided comparable overall ProSeal Laryngeal Mask Airway insertion conditions, although ketamine resulted in significantly better mouth opening and a shorter duration of apnoea.
Why the study?
Does ketamine compared to midazolam as a co-induction agent with propofol improve PLMA insertion conditions and haemodynamic stability in adults undergoing elective surgery?
RCT (n=118)
Double-blind
Computer generated random numbers
No
Does ketamine compared to midazolam as a co-induction agent with propofol improve PLMA insertion conditions and haemodynamic stability in adults undergoing elective surgery?
Ketamine is a preferable co-induction agent with propofol for PLMA insertion compared to midazolam, as it provides better mouth opening, shorter apnoea duration, and superior haemodynamic stability.
Answers are grounded in this paper and cite their sources.
Ketamine may be preferred over midazolam for propofol co-induction in PLMA insertion; extends evidence by confirming specific advantages in mouth opening and apnoea duration.
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Mohamad et al. (2016) conducted an RCT in Patients requiring ProSeal Laryngeal Mask Airway (PLMA) insertion for elective surgery (n=118). Ketamine vs. Midazolam (0.03 mg/kg) was evaluated on Overall satisfactory PLMA insertion conditions (excellent or good). Propofol co-induction with either ketamine or midazolam provided comparable overall ProSeal Laryngeal Mask Airway insertion conditions, although ketamine resulted in significantly better mouth opening and a shorter duration of apnoea.
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