December 1, 2000AJP Heart and Circulatory Physiology

Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Changes in flow, venous pressure, and positive end-expiratory pressure with buffer, RBCs, or Hb. Primary outcome: Expired nitric oxide (NO(e)).

View Full Paper

Ask AI

Bookmark

Key result

Blood and systemic responses obscure changes in vascular NO production, making it difficult to use expired NO changes as an accurate measure of lung tissue NO production.

Population

Anesthetized rabbits and isolated rabbit lungs

Comparison

Changes in flow, venous pressure (P), and… vs Buffer-perfused lungs vs RBC/Hb-perfused lungs…

Design

Preclinical

Authors

JBJohn T. BergVirgen Milagrosa University Foundation SDSteven DeemSwedish Medical Center MKMark E. KerrUniversity of New Mexico

Discussion

Member takes

Implication

Caution against relying on expired NO for lung NO assessment; hypothesis-generating for alternative in vivo measures in pulmonary research.

Structured PICO

Population

Anesthetized rabbits and isolated rabbit lungs

Intervention

Changes in flow, venous pressure (P(v)), and positive end-expiratory pressure (PEEP) with different perfusates (buffer, red blood cells, or hemoglobin)

Comparator

Buffer-perfused lungs vs RBC/Hb-perfused lungs; baseline vs altered mechanical forces

Outcome

Expired nitric oxide (NO(e))surrogate

Blood and systemic responses, particularly hemoglobin NO scavenging, make it difficult to use expired NO changes as an accurate measure of lung tissue NO production.

Cite This Study

Berg et al. (2000) studied this question. Changes in flow, venous pressure, and positive end-expiratory pressure with buffer, RBCs, or Hb was evaluated on Expired nitric oxide (NO(e)). Blood and systemic responses obscure changes in vascular NO production, making it difficult to use expired NO changes as an accurate measure of lung tissue NO production.

synapsesocial.com/papers/6ab73471d2c1437f300e4151 https://doi.org/10.1152/ajpheart.2000.279.6.h2947

View Full Paper

Ask AI

Bookmark

Implication

Caution against relying on expired NO for lung NO assessment; hypothesis-generating for alternative in vivo measures in pulmonary research.

Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider