Why the study?
A treatment target for progressive LV remodeling prevention after MI is to directly affect structural changes within the MI region, but the effects of biocomposite material injections on key remodeling cells were unclear.
Does targeted injection of calcium hydroxyapatite microspheres (CHAM) reduce adverse LV remodeling in adult pigs post-MI?
RCT (n=29)
randomized
Does targeted injection of calcium hydroxyapatite microspheres (CHAM) reduce adverse LV remodeling in adult pigs post-MI?
Targeted injection of calcium hydroxyapatite microspheres into the infarcted myocardium of pigs alters cellular remodeling processes and improves left ventricular function.
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Elisabeth Mahase (2020) conducted an RCT in myocardial infarction (n=29). calcium hydroxyapatite microspheres (CHAM) vs. saline was evaluated on ejection fraction at 21 days (p=<0.05).
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