Key result
Gamma-ray exposure of 15 Gy in rats significantly increased blood nitric oxide voltametric signal height by 17% at 90 min and 25.6% at 24 h, followed by progressive decreases on days 3 and 4.
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No immediate clinical implications; leaves open nitric oxide as a potential biomarker in radiation injury for further preclinical study.
UNLABELLED: PURPOSE. To investigate the effect of blood nitric oxide (NO) as a mediator of the neurovascular syndrome in rats following gamma-irradiation. MATERIAL AND METHODS: Using a voltametric method together with a carbon fibre based sensor, NO measurements were carried out in sham-irradiated and irradiated animals either in blood from the abdominal aorta or in blood samples from the heart. RESULTS: In in vitro conditions, properties of the probe were not altered by the ionizing radiation. Significant increases of +17% and +25.6% were observed in the voltametric signal height at 90 min and 24 h respectively after a 15 Gy gamma-ray exposure. These effects were followed on days 3 and 4 by a progressive decrease in the signal height of 7% and 18% respectively. Dose-effect relationships were observed at 90 min and 24 h after exposure to gamma-rays in the range of 3-15 Gy. Finally, the NO dependence on the measured voltametric signal was controlled by using inhibitors of the NO synthase (NOS) and by performing nitrate assays. CONCLUSIONS: Specific blood NO voltametric measurements are possible. Functional changes associated with NO after gamma-ray exposure are discussed.
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Didier Clarençon (1999) studied Neurovascular syndrome following gamma-irradiation. Gamma-irradiation vs. Sham-irradiated was evaluated on Blood nitric oxide (NO) voltametric signal height. Gamma-ray exposure of 15 Gy in rats significantly increased blood nitric oxide voltametric signal height by 17% at 90 min and 25.6% at 24 h, followed by progressive decreases on days 3 and 4.
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