Key result
Gene transfer of murine IL-4 using adeno-associated virus to the joints of mice with collagen-induced arthritis led to detectable IL-4 levels and protection from articular cartilage destruction.
Why the study?
Does AAV-mediated gene transfer of IL-4 prevent articular cartilage destruction in a murine model of arthritis?
Population
Mice (arthritic and nonarthritic, including a model of collagen-induced arthritis)
Design
Preclinical
Follow-up
at least 7 months
Authors
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Supports AAV-IL-4 gene therapy exploration in arthritis models; leaves open translation to human disease.
Does AAV-mediated gene transfer of IL-4 prevent articular cartilage destruction in a murine model of arthritis?
AAV-mediated gene transfer of IL-4 to the synovium provides long-term expression and protects against cartilage destruction in a murine model of arthritis.
Watanabe et al. (2000) studied collagen-induced arthritis. adeno-associated virus mediated gene transfer of murine IL-4 was evaluated on transgene expression and protection from articular cartilage destruction. Gene transfer of murine IL-4 using adeno-associated virus to the joints of mice with collagen-induced arthritis led to detectable IL-4 levels and protection from articular cartilage destruction.
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