Key result
Morning BP surge correlates moderately with higher UACR in normotensive T2D.
Why the study?
Slight fluctuations in blood pressure regulation without abnormal values appear related to accelerated cardiovascular complications in T2DM patients, with MBPS reported as a predictor of CVD risk.
Is morning blood pressure surge associated with increased levels of microalbuminuria in normotensive patients with type 2 diabetes mellitus?
Observational
Is morning blood pressure surge associated with increased levels of microalbuminuria in normotensive patients with type 2 diabetes mellitus?
Morning blood pressure surge is moderately correlated with microalbuminuria in normotensive patients with type 2 diabetes, suggesting it may serve as an early marker for microvascular complications.
May indicate early microvascular risk in normotensive T2DM; hypothesis-generating and requires prospective validation before clinical consideration.
Background: The slight fluctuations in blood pressure (BP) regulation even without advancing to abnormal values appear to be related to more accelerated cardiovascular complications in patients with type 2 diabetes mellitus (T2DM). Morning blood pressure surge (MBPS) has been increasingly reported to provide a significant predictor of cardiovascular disease (CVD) risk.Aim: To study the whether MBPS is associated with increased levels of microalbuminuria in normotensive T2DM patients.Patients and methods: Normotensive T2DM patients were subjected to ambulatory blood pressure monitoring (ABPM) and urine spot sampling to assess urine albumin creatinine ratio (UACR).Results: 32% of patients had microalbuminuria with a highly significant moderate positive correlation between UACR with DM duration, MBPS and average 2-hours systolic blood pressure (SBP) with (r = 0.342) p-value
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Abdel-Kareem et al. (2019) conducted an observational in Type 2 diabetes mellitus. Morning blood pressure surge (MBPS) was evaluated on Microalbuminuria (assessed by urine albumin creatinine ratio) (r = 0.342). Morning blood pressure surge showed a highly significant moderate positive correlation with urine albumin creatinine ratio (r = 0.342) in normotensive patients with type 2 diabetes mellitus.
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