Key result
Pretreatment with 100 μM trans-10,cis-12-CLA exerted higher anti-inflammatory effects than cis-9,trans-11-CLA by significantly downregulating inflammation-related genes in ruminal epithelial cells.
Population
Ruminal epithelial cells (RECs) in vitro stimulated with lipopolysaccharide (LPS)
Comparison
Pretreatment with 100 μM trans-10,cis-12-CLA or… vs LPS stimulation alone (LPS group)
Design
Preclinical
Authors
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Hypothesis-generating for CLA isomer effects in epithelial inflammation; should not yet change practice or guide trials.
In ruminal epithelial cells, the trans-10,cis-12-CLA isomer exhibits stronger anti-inflammatory effects against LPS-induced inflammation compared to the cis-9,trans-11-CLA isomer.
Yang et al. (2021) studied LPS-induced inflammation of ruminal epithelial cells. trans-10,cis-12-CLA vs. cis-9,trans-11-CLA and LPS alone was evaluated on Expression of genes related to inflammation, cell proliferation and migration. Pretreatment with 100 μM trans-10,cis-12-CLA exerted higher anti-inflammatory effects than cis-9,trans-11-CLA by significantly downregulating inflammation-related genes in ruminal epithelial cells.
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