Key result
Lower Body Negative Pressure (LBNP) can be used to simulate hemorrhage and assess the compensatory reserve during progressive reductions in central blood volume.
Why the study?
How is compensatory reserve assessed during progressive reductions in central blood volume using LBNP as a simulation of hemorrhage?
How is compensatory reserve assessed during progressive reductions in central blood volume using LBNP as a simulation of hemorrhage?
Lower Body Negative Pressure (LBNP) can be used as a human model to simulate hemorrhage and assess compensatory reserve via arterial waveform changes.
LBNP enables controlled study of compensatory reserve in simulated hypovolemia; leaves open translation to clinical hemorrhage without prospective validation.
Hemorrhage is the leading cause of trauma-related deaths, partly because early diagnosis of the severity of blood loss is difficult. Assessment of hemorrhaging patients is difficult because current clinical tools provide measures of vital signs that remain stable during the early stages of bleeding due to compensatory mechanisms. Consequently, there is a need to understand and measure the total integration of mechanisms that compensate for reduced circulating blood volume and how they change during ongoing progressive hemorrhage. The body's reserve to compensate for reduced circulating blood volume is called the 'compensatory reserve'. The compensatory reserve can be accurately evaluated with real-time measurements of changes in the features of the arterial waveform measured with the use of a high-powered computer. Lower Body Negative Pressure (LBNP) has been shown to simulate many of the physiological responses in humans associated with hemorrhage, and is used to study the compensatory response to hemorrhage. The purpose of this study is to demonstrate how compensatory reserve is assessed during progressive reductions in central blood volume with LBNP as a simulation of hemorrhage.
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Convertino et al. (2016) studied Hemorrhage. Lower Body Negative Pressure (LBNP) was evaluated on Assessment of compensatory reserve during progressive reductions in central blood volume. Lower Body Negative Pressure (LBNP) can be used to simulate hemorrhage and assess the compensatory reserve during progressive reductions in central blood volume.
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