Key result
Low body mass index (< 22 kg/m2) was associated with a significantly higher risk of major adverse cardiac and cerebrovascular events at three years compared to high body mass index (≥ 26 kg/m2) in patients with acute myocardial infarction (adjusted HR 1.23).
Why the study?
The clinical outcomes of patients treated for AMI according to different BMI levels and the concept of the BMI paradox were not fully understood.
Does lower BMI increase the risk of major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction undergoing PCI?
Cohort (n=10,566)
Yes
Does lower BMI increase the risk of major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction undergoing PCI?
Introduction: Body mass index (BMI), as an important risk factor related to metabolic disease. However, in some studies higher BMI was emphasized as a beneficial factor in the clinical course of patients after acute myocardial infarction (AMI) in a concept known as the “BMI paradox.” The purpose of this study was to investigate how clinical outcomes of patients treated for AMI differed according to BMI levels. Methods A total of 10,566 patients in the Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) from May 2010 to June 2015 were divided into three BMI groups (group 1: BMI < 22 kg/m2, group 2: ≥ 22 and < 26 kg/m2, and group 3: ≥ 26 kg/m2). The primary outcome was major adverse cardiac and cerebrovascular event (MACCE) at three years of follow-up. Results At one year of follow-up, the incidence of MACE in group 1 was 10.1% of that in group 3, with a hazard ratio (HR) of 2.27, and 6.5% in group 2, with an HR of 1.145. This tendency continued up to three years of follow-up. Conclusion The study demonstrated that higher BMI could exert a positive effect on the clinical outcomes of patients with AMI undergoing percutaneous coronary intervention (PCI).
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Park et al. (2023) conducted a cohort in Acute myocardial infarction (n=10,566). Low body mass index (< 22 kg/m2) vs. High body mass index (≥ 26 kg/m2) was evaluated on Major adverse cardiac and cerebrovascular event (MACCE) at 3 years (Adjusted HR 1.230, 95% CI 1.030-1.469, p=0.022). Low body mass index (< 22 kg/m2) was associated with a significantly higher risk of major adverse cardiac and cerebrovascular events at three years compared to high body mass index (≥ 26 kg/m2) in patients with acute myocardial infarction (adjusted HR 1.23).
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