Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: XV. N,N′-(Alkane-α,ω-diyl)bis[N′-(adamantan-1-yl)]selenoureas

A series of N,N′-(alkane-α,ω-diyl)bis[N′-(adamantan-1-yl)selenoureas] have been synthesized in 27–84% yields by the reaction of adamantan-1-yl isoselenocyanate with alkane-α,ω-diamines. The synthesized compounds melted in the range 105–164°C, which is lower by ~80°C than the melting point range of their isosteric analogs containing urea fragments. N,N′-(Alkane-α,ω-diyl)bis[N′-(adamantan-1-yl)selenoureas] are promising as inhibitors of human soluble epoxide hydrolase.