Key result
Maternal prednisone and triamcinolone treatment fails to suppress neonatal cortisol production rates.
Why the study?
The effect of maternal treatment with pharmacologic doses of prednisone and triamcinolone on cortisol production rate in offspring was unclear.
Does maternal treatment with pharmacologic doses of prednisone and triamcinolone suppress the cortisol production rate of their offspring?
Does maternal treatment with pharmacologic doses of prednisone and triamcinolone suppress the cortisol production rate of their offspring?
Maternal treatment with pharmacologic doses of corticosteroids does not appear to suppress the cortisol production rate in offspring.
Maternal steroids may not suppress offspring CPR; leaves open questions on adrenal function in anencephaly and requires larger studies before clinical inference.
Treatment of pregnant mothers with pharmacologic doses of prednisone and triamcinolone did not suppress the CPR of their offspring. Babies of diabetic mothers and infants with autosomal trisomy had normal CPR's. Two infants with anencephaly had a CPR in the lower range of normal.
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Kenny et al. (1966) studied this question. Maternal treatment with pharmacologic doses of prednisone and triamcinolone did not suppress the cortisol production rate of their offspring.
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