Synthesis of two novel oxocyclam‐binding technetium complexes containing an analogue of cocaine

In order to visualize and quantify dopamine transporters, the synthesis of two novel ligands labelled with technetium‐99 m (99mTc) has been investigated. A multi‐step synthesis afforded two target ligands with a tropane skeleton and a macrocyclic complexing moiety. The choice and the position of substituents are in adequation with dopamine transporter structure. The radiolabelling of these ligands with 99mTc has been studied and the results make them good candidates for SPECT imaging.