Key result
Rescue LMCA stenting restores flow and maintains 1-year patency in pediatric homozygous familial hypercholesterolemia.
Why the study?
Homozygous familial hypercholesterolemia leads to premature atherosclerosis and coronary artery disease, with limited data on emergency coronary stenting in pediatric patients.
Case Report (n=1)
Coronary artery stent implantation may be a valid rescue therapeutic alternative for pediatric patients with homozygous familial hypercholesterolemia and severe ostial coronary stenosis in emergencies.
May support emergency stenting in pediatric HFH; leaves open need for prospective data on long-term safety and efficacy.
Homozygous familial hypercholesterolemia (HFH), resulting from mutation of the low-density lipoprotein (LDL) receptor gene with subsequent defective catabolism of the LDL cholesterol, leads to premature atherosclerosis and coronary artery disease. We report a successful urgent stent implantation in a 7-year-old patient with HFH and a severe left main coronary artery stenosis, who presented critical acute myocardial ischemia immediately after left coronary angiography. Percutaneous transluminal coronary angiography with stent implantation allowed for rapid coronary flow reestablishment without sequelae. Aggressive lipid-lowering therapy with high doses statins and LDL-apheresis was maintained, together with lifelong antiaggregant acetylsalicylic treatment with good short-term patency of the stent at 1-year follow-up. In conclusion, coronary artery stent implantation may be considered as a valid rescue therapeutic alternative for pediatric patients with HFH and severe ostial coronary stenosis in case of emergency.
No takes yet. Share an insight, caveat, or question.
Tissot et al. (2006) conducted a case report in Homozygous familial hypercholesterolemia with acute myocardial ischemia (n=1). Rescue left main coronary artery stenting was evaluated on Coronary flow reestablishment and stent patency. Rescue left main coronary artery stenting allowed for rapid coronary flow reestablishment with good short-term patency at 1-year follow-up in a 7-year-old girl with HFH.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: