Key result
Ethanol consumption significantly lowered the alpha2 amplitude when consumed in the morning, and lowered P300 amplitude and search speed when consumed in the evening.
Why the study?
Does the time of day of ethanol consumption affect EEG topography and cognitive event-related potentials in healthy adult males?
RCT (n=9)
Counterbalanced
No
Does the time of day of ethanol consumption affect EEG topography and cognitive event-related potentials in healthy adult males?
The physiological and cognitive effects of ethanol consumption in healthy males vary depending on the time of day it is consumed.
Morning ethanol may alter EEG more than evening intake; hypothesis-generating for chronobiology of alcohol effects.
Time-of-day effects of ethanol consumption on EEG topography and cognitive event-related potential in adult males were studied. Ethanol (0.5 g/kg) or control drink was orally administered to nine healthy males at 10:00 and 18:00. The alpha 2 amplitude was significantly lower than that of the control at 0.5, 2.5 and 4.5 hours after ethanol consumption in the morning. These effects were observed in the left hemisphere and were only found after consumption in the morning. The subjectively rated attention was significantly lower than that of the control at 0.5 and 2.5 hours after ethanol consumption in the morning and at 0.5 hours after ethanol consumption in the evening. In contrast, the search speed of serial search task and P300 amplitude was significantly lower than that of the control at 2.5 hours after ethanol consumption in the evening. These results demonstrate that effects of ethanol are dependent on time-of-day of consumption. Ethanol consumption significantly lowered the alpha 2 amplitude when consumed in the morning, and lowered P300 amplitude when consumed in the evening.
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Liu et al. (2000) conducted an RCT in Healthy (n=9). Ethanol vs. Control drink (orange juice) was evaluated on Alpha2 amplitude at Cz with eyes open (p=<0.05). Ethanol consumption significantly lowered the alpha2 amplitude when consumed in the morning, and lowered P300 amplitude and search speed when consumed in the evening.
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