Key result
Novel aggregation model explains how capillary systems mature into interdigitating 3-D vasculatures without shunting.
Why the study?
The mechanisms by which the capillary system matures into two interdigitated 3-D arborescent vasculatures without direct shunts are not fully understood.
This computational model provides a theoretical framework for understanding the 3-D maturation and interdigitation of capillary systems.
May inform microvascular research but should not change practice; leaves open validation in clinical settings.
We present a model of 3-D vascular formation which is able to explain how the capillary system matures into two 3-D arborescent vasculatures which interdigitate in the distal parts, without forming direct shunts.
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Fleury et al. (2000) studied this question. An interlaced diffusion limited aggregation model explains how the capillary system matures into two interdigitating 3-D arborescent vasculatures without forming direct shunts.
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