Why the study?
Is serum angiopoietin-1 level an effective biomarker for missed abortion in early pregnancy?
Case-Control (n=100)
No
Is serum angiopoietin-1 level an effective biomarker for missed abortion in early pregnancy?
Serum angiopoietin-1 levels are significantly lower in women with missed abortion compared to those with normal viable pregnancies, suggesting its potential utility as a biomarker.
May support angiopoietin-1 as a biomarker for missed abortion; hypothesis-generating and should not yet change practice.
Objective: To detect serum angiopoietin -1 level as effective biomarker for missed abortion in early pregnancy. Methods: The study included 100 pregnant women; 50 pregnant women with missed abortion (group A) and 50 pregnant women with viable intrauterine pregnancy in first trimester (group B). Both groups were test for serum level of angiopoietin -1 using Enzyme linked immunosorbent assay technique. Results: The mean serum angiopoietin -1 level is significantly decrease in missed abortion compare with control group women (771.12 ± 165 VS 1381.12 ± 340.36) respectively at P value (0.001). There was correlation between missed abortion and (body mass index, reproductive history) in groups of study. Conclusion: The current study showed that serum levels of angiopoitin-1 are significantly decrease in pregnant women with missed abortion compared with its level in normal viable intrauterine pregnancy of matched gestation.
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Bayati et al. (2022) conducted a case-control in Missed abortion (n=100). Serum angiopoietin-1 vs. Viable intrauterine pregnancy was evaluated on Mean serum angiopoietin-1 level (pg/ml) (p=0.001).
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