Key result
Transfemoral TAVI linked to ~71% lower delirium risk vs transapical approach.
Why the study?
Delirium frequency after transcatheter aortic valve implantation via the femoral artery compared with the cardiac apex was uncertain.
Does transfemoral transcatheter aortic valve implantation reduce postoperative delirium compared to transapical implantation?
Cohort (n=210)
Does transfemoral transcatheter aortic valve implantation reduce postoperative delirium compared to transapical implantation?
Absolute Event Rate: 10% vs 35%
p-value: p=0.0001
Transfemoral TAVI is associated with a significantly lower rate of postoperative delirium and shorter hospital stay compared to transapical TAVI.
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May guide TAVI access selection to reduce delirium; leaves open causal confirmation in randomized trials.
Sharma et al. (2016) conducted a cohort in Transcatheter aortic valve implantation (n=210). Transfemoral transcatheter aortic valve implantation vs. Transapical transcatheter aortic valve implantation was evaluated on Delirium in the 3 days after valve implantation (p=0.0001). Transfemoral transcatheter aortic valve implantation was associated with a significantly lower rate of delirium at 3 days compared to the transapical approach (10% vs 35%, p=0.0001).
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