Key result
Shared biological pathways, including hyperglycaemia, microvascular dysfunction, and low-grade inflammation, are proposed to underlie the bidirectional relationship between type 2 diabetes and depression.
Shared biological pathways like microvascular dysfunction and inflammation may link type 2 diabetes and depression, but longitudinal studies are needed to confirm temporal relationships.
Depression is twice as common in type 2 diabetes as in the general population and is associated with adverse health outcomes. Growing evidence suggest that type 2 diabetes and depression share biological mechanisms. This brief commentary discusses current understanding of shared biological pathways, focussing on hyperglycaemia, (micro)vascular dysfunction, and low-grade inflammation. Although there is accumulating evidence that these pathways are involved in the link between type 2 diabetes and depression, direct evidence of their temporal associations is lacking because of a paucity of longitudinal studies that focus on the pathobiology of both type 2 diabetes and depression.
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Sloten et al. (2018) conducted a review in Type 2 diabetes and depression. Biological pathways (hyperglycaemia, microvascular dysfunction, low-grade inflammation) was evaluated. Shared biological pathways, including hyperglycaemia, microvascular dysfunction, and low-grade inflammation, are proposed to underlie the bidirectional relationship between type 2 diabetes and depression.
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