σH-Adducts of 2-R-6-Nitro-1,2,4-triazolo[1,5-a]pyrimidines Containing a 2,5-Disubstituted Tetrazole Fragment in the Molecule

A method for the direct introduction of 2-(R-phenacyl)methyl-5-aryl(heteryl)tetrazole fragments into the molecule of 2-R-6-nitro-1,2,4-triazolo[1,5-a]pyrimidines via a nucleophilic addition reaction has been developed. The antimicrobial activity of some synthesized compounds was evaluated against the reference strain Neisseria gonorrhoeae ATCC 49226/NCTC 12700 and museum strains of dermatophyte and yeast-like fungi.