Key result
A closed-loop artificial pancreas control system significantly increased the percentage of glucose concentration within the target range compared to open-loop control (58% vs 54%, P<.01).
Why the study?
Does a closed-loop artificial pancreas control system reduce hypoglycemia and improve time in target glucose range in patients with type 1 diabetes?
Population
Patients with type 1 diabetes undergoing 11 open-loop and 9 closed-loop experiments
Comparison
Closed-loop artificial pancreas control system vs Open-loop (OL) experiments
Design
Other
Authors
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Hypothesis-generating for closed-loop systems; leaves open validation in larger, diverse populations before clinical adoption.
Does a closed-loop artificial pancreas control system reduce hypoglycemia and improve time in target glucose range in patients with type 1 diabetes?
Absolute Event Rate: 58% vs 54%
p-value: p=<.01
An integrated multivariable artificial pancreas control system with a hypoglycemia early alarm effectively maintains glucose within target range and prevents hypoglycemia in type 1 diabetes.
Turksoy et al. (2014) studied Type 1 diabetes. Closed-loop artificial pancreas control system vs. Open-loop control was evaluated on Percentage of glucose concentration within target range (70-180 mg/dl) (p=<.01). A closed-loop artificial pancreas control system significantly increased the percentage of glucose concentration within the target range compared to open-loop control (58% vs 54%, P<.01).
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