Key result
Pancreas transplant thrombosis stems from Virchow's triad, requiring targeted risk mitigation and controlled anticoagulation.
Why the study?
Thrombosis of the transplanted pancreas is a common and often catastrophic event with multiple predisposing factors requiring clinical management guidance.
Provides an overview of predisposing factors and clinical management strategies for pancreas allograft thrombosis.
Supports perioperative risk-factor optimization and anticoagulation in pancreas transplantation; leaves open optimal protocols for prospective trials.
Thrombosis of the transplanted pancreas is a common and often catastrophic event. Predisposing factors include the hypercoagulable state of many patients with diabetic renal failure, preservation-related graft endothelial injury, and low-velocity venous flow. Clinical management includes optimization of modifiable risk factors, controlled anticoagulation, graft monitoring, and early therapeutic intervention.
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Muthusamy et al. (2010) conducted a review in Pancreas Allograft Thrombosis. Thrombosis of the transplanted pancreas is predisposed by hypercoagulable states, endothelial injury, and low-velocity flow, requiring optimization of risk factors and controlled anticoagulation.
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