Key result
Adipolin attenuates neointimal thickening after vascular injury by curbing macrophage inflammation and muscle cell proliferation.
Why the study?
The role of adipolin in vascular disease and pathological vascular remodelling was previously unknown.
Population
Adipolin-knockout and wild-type mice subjected to wire-induced femoral artery injury
Comparison
Adipolin deficiency versus wild-type
Design
Preclinical experimental study with in vivo and in vitro components
Authors
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Hypothesis-generating for adipolin in vascular remodeling; human studies required before any clinical consideration.
Adipolin protects against pathological vascular remodeling by attenuating macrophage inflammatory responses and VSMC proliferation.
Ogawa et al. (2019) studied Pathological vascular remodelling. Adipolin deficiency (APL-KO) and adipolin protein treatment vs. Wild-type (WT) mice and untreated cells was evaluated on Neointimal thickening after vascular injury. Adipolin deficiency increased neointimal thickening after vascular injury in mice, while adipolin treatment attenuated macrophage inflammatory responses and vascular smooth muscle cell proliferation.
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