Key result
CTRP9 protects against acute cardiac damage in response to pathological stimuli by suppressing inflammatory reactions through AdipoR1/AMPK-dependent mechanisms.
Population
12-week-old CTRP9-knockout mice, wild-type mice, muscle-specific transgenic mice expressing…
Comparison
Loss-of-function genetic manipulations… vs Wild-type (WT) mice and baseline conditions
Design
Preclinical
Authors
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Hypothesis-generating for CTRP9-targeted therapy in cardiac injury; human studies required before clinical translation.
CTRP9 protects against acute myocardial injury and inflammation through an AdipoR1-AMPK-dependent signaling pathway.
Kambara et al. (2015) studied Acute myocardial injury. CTRP9 (genetic knockout and systemic protein delivery) vs. Wild-type mice / baseline conditions was evaluated on Cardiac dysfunction, myocardial infarct size, and inflammatory mediator expression. CTRP9 protects against acute cardiac damage in response to pathological stimuli by suppressing inflammatory reactions through AdipoR1/AMPK-dependent mechanisms.
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