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June 1, 2012The Medicine ForumOpen Access

C1q/Tumor Necrosis Factor-Related Protein-3, a Newly Identified Adipokine, Is a Novel Antiapoptotic, Proangiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart

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Why the study?

Does exogenous CTRP3 replenishment improve postischemic cardiac remodeling and cardiac dysfunction in a mouse model of myocardial infarction?

Population

Male adult mice subjected to myocardial infarction via left anterior descending coronary artery occlusion…

Comparison

Exogenous CTRP3 replenishment vs Control (not explicitly described in abstract)

Design

Preclinical

Authors

WYWei YiYSYang SunYYYuexing Yuan

Discussion

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Member takes

Overview

CTRP3 merits testing as post-MI therapy in larger models; leaves open translation to human trials.

Structured PICO

Does exogenous CTRP3 replenishment improve postischemic cardiac remodeling and cardiac dysfunction in a mouse model of myocardial infarction?

P
Population
Male adult mice subjected to myocardial infarction (MI) via left anterior descending coronary artery occlusion, and human umbilical vascular endothelial cells (HUVECs)
I
Intervention
Exogenous CTRP3 replenishment (adenovirus or recombinant CTRP3)
C
Comparator
Control (not explicitly described in abstract)
O
Outcome
Survival rate, cardiac function, cardiomyocyte apoptosis, revascularization, and interstitial fibrosissurrogate

CTRP3 is a novel antiapoptotic, proangiogenic, and cardioprotective adipokine that improves survival and cardiac remodeling after myocardial infarction in a preclinical mouse model.

Cite This Study

Yi et al. (2012) studied this question.

synapsesocial.com/papers/6a70c509abc331a858079ef8https://doi.org/10.1161/circulationaha.112.099937
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