Why the study?
Does CTRP3 overexpression exacerbate pressure overload-induced cardiac hypertrophy in mice?
Population
Mice subjected to pressure overload, cardiomyocyte-specific CTRP3 overexpression/knockdown models, and…
Comparison
Cardiomyocyte-specific CTRP3 overexpression or… vs Control mice/cardiomyocytes
Design
Preclinical
Authors
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CTRP3 modulation merits exploration as a hypertrophy target; these Level 5 findings leave open human relevance and require prospective validation.
Does CTRP3 overexpression exacerbate pressure overload-induced cardiac hypertrophy in mice?
CTRP3 promotes pressure overload-induced cardiac hypertrophy via activation of the TAK1-JNK axis, highlighting a novel mechanism in the development of cardiac hypertrophy.
Ma et al. (2018) studied this question.
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