Why the study?
Does CTRP9 modulation affect cardiac hypertrophy and failure in response to pressure overload?
Population
Hypertrophic human hearts, serum from patients with severe aortic stenosis, mouse models of transverse…
Comparison
CTRP9 gene deletion, CTRP9 overexpression, and… vs Wild-type mice and control conditions
Design
Preclinical
Authors
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CTRP9 may drive endothelial-cardiomyocyte crosstalk in overload; leaves open its therapeutic relevance in human HF.
Does CTRP9 modulation affect cardiac hypertrophy and failure in response to pressure overload?
Upregulation of endothelial-derived CTRP9 during pressure overload promotes maladaptive cardiac hypertrophy and dysfunction via the ERK5-GATA4 pathway, identifying it as a potential therapeutic target.
Appari et al. (2016) studied this question.
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