Key result
Overexpression of the S1 Spike protein of PEDV and other coronaviruses effectively induced host cell apoptosis, identifying it as a critical functional protein for coronavirus-mediated apoptosis.
Population
Host cells including Vero, Vero-E6 and Marc-145
Comparison
Overexpression of S1 Spike protein of PEDV and… vs Overexpression of other non-structural and…
Design
Preclinical
Authors
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S1 may mediate coronavirus apoptosis; extends in vitro observations but leaves open in vivo relevance and therapeutic targeting.
p-value: p=<0.001
The S1 Spike protein of PEDV and other coronaviruses is a critical inducer of host cell apoptosis.
Chen et al. (2018) studied Porcine Epidemic Diarrhea Virus (PEDV) Infection. PEDV S1 protein overexpression vs. Mock infection or empty vector (pEGFP-N1) was evaluated on Cell apoptosis (Annexin V positive cells) (p=<0.001). Overexpression of the S1 Spike protein of PEDV and other coronaviruses effectively induced host cell apoptosis, identifying it as a critical functional protein for coronavirus-mediated apoptosis.
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