Key result
Higher admission secretoneurin linked to ~3-fold higher hospital mortality in severe sepsis.
Why the study?
Secretoneurin provides incremental prognostic information in cardiovascular disease, but its prognostic value in critically ill patients with infections was unclear.
Do admission secretoneurin levels predict hospital mortality and shock in critically ill patients with severe infections?
Observational (n=326)
Yes
Do admission secretoneurin levels predict hospital mortality and shock in critically ill patients with severe infections?
Odds Ratio: 3.17 (95% CI 1.12–9)
p-value: p=0.030
Secretoneurin levels measured early after ICU admission provide incremental prognostic information beyond established risk indices for predicting hospital mortality and shock in critically ill patients with severe infections.
May refine prognosis in critically ill infected patients; leaves open whether it alters management or warrants prospective validation.
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Røsjø et al. (2016) conducted an observational in Critically ill patients with infections (n=326). Admission secretoneurin levels vs. Lower secretoneurin levels / established risk indices was evaluated on Hospital mortality (OR 3.17, 95% CI 1.12-9.00, p=0.030). Higher admission secretoneurin levels were significantly associated with increased hospital mortality (OR 3.17; 95% CI 1.12-9.00; p=0.030) in critically ill patients with severe sepsis.
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