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Mesenchymal stromal cells (MSC) are multipotent cells that can self-renew and at the same time differentiate into multiple lineages with specific surface marker expression. During the past several years, MSCs have generated a great deal of interest in many clinical settings, including regenerative medicine, immune modulation, and tissue engineering. Many studies have demonstrated their remarkable tumor tropic properties. Several pre-clinical and clinical studies have demonstrated the efficacy of genetically modified MSC to express and release therapeutic factors, confirming their ability to serve as an excellent base for cell-mediated gene therapy. This chapter will review the literature on the use of MSCs as a therapeutic drug delivery system.
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Menon et al. (2009) studied this question.