Synthetic chemistry study demonstrates efficient one-pot formation of Corynanthe indole alkaloids, highlighting a stereoselective dual-cyclization strategy.
Biologically active indole alkaloids are accessible in a convergent and stereoselective fashion by the sequential intramolecular ene reaction of starting compounds such as 1. The first cyclization to 2 in this one-pot procedure is triggered by trifluoroacetic acid, the second by SnCl4.
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Tietze et al. (1992) studied this question.
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