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Indomethacin treatment of rats resulted in a significant increase of pineal monoamine oxidase (MAO) type A activity, whereas it depressed MAO type B and hydroxyindole-O-methyl transferase activities. Indomethacin also significantly impaired the nocturnal rise of pineal serotonin-N-acetyltransferase activity and melatonin content. These results suggest a role for prostaglandins in the regulation of pineal function.
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Ritta et al. (2008) studied this question.
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