Solid‐Phase Synthesis of Peptide Thioesters with Self‐Purification

This is the authors' abstract. We don't add key points for this paper.

Separating the wheat from the chaff: A cyclization–thiolysis sequence adds a new property to sulfonamide safety-catch resins. Activation of the sulfonamide is used to introduce a carboxy group for subsequent macrocyclization. Truncation products are noncyclic and hence washed away following thiolytic ring opening. Only the full-length peptide thioesters are detached, usually in pure form, in the final step.