Key result
High fasting blood glucose is linked to severe coronary atherosclerosis in non-diabetic patients.
Why the study?
The predictive value of high fasting blood glucose for serious coronary lesions in non-diabetic patients with coronary artery disease was unclear.
Does high fasting blood glucose predict serious coronary lesions (Gensini score >41) in non-diabetic patients undergoing coronary angiography?
Observational (n=64)
Does high fasting blood glucose predict serious coronary lesions (Gensini score >41) in non-diabetic patients undergoing coronary angiography?
High fasting blood glucose is an independent predictor of severe coronary artery disease in non-diabetic patients presenting with chest discomfort.
OBJECTIVE: To determine if high fasting blood glucose (FBG) level is an independent predictor of serious coronary lesions in patients with coronary artery disease (CAD). METHODS: We enrolled 64 patients who had symptoms of chest discomfort and who underwent coronary angiography. FBG was determined from blood samples and the extent of coronary artery lesions was analyzed according to Gensini score. We examined the relationships among diabetes, FBG, and coronary artery severity. RESULTS: Diabetes and FBG were significantly and positively related to Gensini score. Diabetes, but not FBG, was independently correlated with the occurrence of a Gensini score >41. However, FBG was significantly associated with Gensini score >41 in non-diabetic patients. CONCLUSION: Hyperglycemia is an independent predictor of severe CAD in non-diabetic patients. Clinicians should be aware of this and should carry out appropriate early interventions.
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Zhao et al. (2018) conducted an observational in Coronary artery disease (n=64). High fasting blood glucose was evaluated on Serious coronary lesions (Gensini score >41). High fasting blood glucose was significantly associated with severe coronary atherosclerosis (Gensini score >41) in non-diabetic patients.
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