Key result
Re-treatment with interferon alfa yielded a sustained response in 19% of relapsers and 3% of nonresponders, occurring only with augmented dose or duration of therapy.
Why the study?
Does re-treatment with interferon alfa improve sustained response in patients with chronic hepatitis C who failed initial therapy?
Population
111 patients with chronic hepatitis C who failed to achieve sustained response after one standard course of…
Comparison
Re-treatment with interferon alfa. vs Different regimens of interferon alfa…
Design
Cohort
Authors
Loading...
Limited sustained response rates caution against routine interferon re-treatment in prior failures; leaves open whether augmented dosing improves outcomes.
Cohort (n=111)
Does re-treatment with interferon alfa improve sustained response in patients with chronic hepatitis C who failed initial therapy?
Sustained response to interferon alfa re-treatment in chronic hepatitis C patients who failed initial therapy is low and only observed with increased dose or duration.
Chow et al. (1998) conducted a cohort in chronic hepatitis C (n=111). Re-treatment with interferon alfa vs. Same regimen as first treatment was evaluated on Sustained response to re-treatment. Re-treatment with interferon alfa yielded a sustained response in 19% of relapsers and 3% of nonresponders, occurring only with augmented dose or duration of therapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: