Key result
Remdesivir linked to QTc prolongation, palpitations, and syncope in severe COVID-19.
Why the study?
The association between remdesivir therapy and QTc interval prolongation in patients with severe COVID-19 has only been observed in a few cases despite known cardiac side effects.
Does remdesivir therapy cause QTc prolongation in patients with severe COVID-19?
Case Report (n=1)
Does remdesivir therapy cause QTc prolongation in patients with severe COVID-19?
Remdesivir therapy in severe COVID-19 patients may be associated with QTc prolongation, highlighting the need for ECG monitoring.
Answers are grounded in this paper and cite their sources.
Remdesivir may be associated with QTc prolongation; single case leaves open causality and need for prospective monitoring studies.
Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged on the Electrocardiogram (ECG) without any significant electrolyte abnormalities or concomitant use of medications with QTc prolongation. Although the cardiac side effects of remdesivir therapy have been well documented, the link between remdesivir therapy and QTc interval prolongation in patients with severe COVID-19 has only been observed in a few cases. Because this arrhythmia has the potential to result in sudden cardiac death, practitioners should be aware of the QTc interval prolongation associated with remdesivir therapy.
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Harbi et al. (2022) conducted a case report in Severe COVID-19 pneumonia (n=1). Remdesivir was evaluated on QTc interval prolongation, palpitations, and syncope. Remdesivir therapy was associated with QTc interval prolongation, palpitations, and syncope in a critically ill patient with severe COVID-19 pneumonia.
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