Key result
A 61-year-old woman with poorly compliant hypothyroidism developed rhabdomyolysis and acute renal failure after strenuous walking, which resolved with peritoneal dialysis and levothyroxine.
Case Report (n=1)
No
Rhabdomyolysis can occur in patients with poorly compliant hypothyroidism, especially when combined with aggravating factors like exercise.
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Hypothyroid myopathy may trigger exertional rhabdomyolysis with renal failure; single case leaves open need for compliance-focused prevention strategies.
A 61-year-old woman developed rhabdomyolysis and acute renal failure after strenuous walking. She had been treated for seven years with levothyroxine (T4) for hypothyroidism. On admission, her thyroid function test revealed marked hypothyroidism, suggesting poor drug compliance. Electromyographic and muscle biopsy findings were compatible with hypothyroid myopathy. Other diseases that could cause rhabdomyolysis were excluded. Her renal function completely recovered with peritoneal dialysis, and thyroid function normalized with 100 micrograms/day of T4. The present case suggests that rhabdomyolysis could occur in patients with hypothyroidism, especially those with poor drug compliance, in combination with other aggravating factors such as exercise.
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Sekine et al. (1993) conducted a case report in Hypothyroidism, rhabdomyolysis, acute renal failure (n=1). Strenuous walking during poorly compliant hypothyroidism was evaluated on Clinical recovery. A 61-year-old woman with poorly compliant hypothyroidism developed rhabdomyolysis and acute renal failure after strenuous walking, which resolved with peritoneal dialysis and levothyroxine.
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