Key result
Aspirin use in hospitalized COVID-19 patients was associated with a decreased risk of mechanical ventilation (35.7% vs 48.4%; adjusted HR 0.56; 95% CI 0.37-0.85; P=0.007).
Why the study?
Does aspirin use reduce the need for mechanical ventilation, ICU admission, and in-hospital mortality in adult patients hospitalized with COVID-19?
Population
412 adult patients admitted with COVID-19 to multiple hospitals in the United States between March 2020 and…
Comparison
Aspirin received within 24 hours of admission or… vs No aspirin received
Design
Cohort
Authors
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May support aspirin evaluation in COVID-19 RCTs; leaves open any practice change.
Cohort (n=412)
Yes
Does aspirin use reduce the need for mechanical ventilation, ICU admission, and in-hospital mortality in adult patients hospitalized with COVID-19?
Hazard Ratio: 0.56 (95% CI 0.37–0.85)
Absolute Event Rate: 35.7% vs 48.4%
p-value: p=.007
In hospitalized COVID-19 patients, aspirin use is associated with a significantly lower risk of mechanical ventilation, ICU admission, and in-hospital mortality without increasing major bleeding.
Chow et al. (2020) conducted a cohort in COVID-19 (n=412). Aspirin vs. No aspirin was evaluated on Need for mechanical ventilation (adjusted HR 0.56, 95% CI 0.37-0.85, p=.007). Aspirin use in hospitalized COVID-19 patients was associated with a decreased risk of mechanical ventilation (35.7% vs 48.4%; adjusted HR 0.56; 95% CI 0.37-0.85; P=0.007).
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