Key result
Combined autonomic stimulation increases AF inducibility to ~100% compared to baseline.
Why the study?
The effects of acute vagal and sympathetic stimulation on atrial and pulmonary vein electrophysiology and atrial fibrillation inducibility require better understanding in a fully innervated in vivo model.
Does acute autonomic nervous system stimulation alter atrial electrophysiology and promote AF inducibility in an in vivo rabbit model?
Does acute autonomic nervous system stimulation alter atrial electrophysiology and promote AF inducibility in an in vivo rabbit model?
p-value: p=<0.05
Acute autonomic nervous system stimulation shortens atrial and pulmonary vein refractoriness and alters conduction times, significantly increasing the inducibility and duration of atrial fibrillation in an in vivo rabbit model.
No takes yet. Share an insight, caveat, or question.
Acute ANS stimulation promotes AF in rabbit hearts; leaves open translation to human AF substrate or management.
Oliveira et al. (2012) studied Atrial fibrillation (n=17). Acute vagal and sympathetic stimulation vs. Baseline was evaluated on Atrial fibrillation inducibility (p=<0.05). Acute autonomic nervous system stimulation significantly increased AF inducibility from 35-53% at baseline to 75-100% with combined vagal and sympathetic stimulation (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: