Key result
Arterial concentrations of propofol were significantly higher than venous concentrations during a 40-minute infusion (difference -28.8% ± 18.3%), a relationship that reversed after the infusion.
Why the study?
Are venous concentrations of propofol useful to estimate arterial values during and after a stepdown infusion in healthy adults?
Are venous concentrations of propofol useful to estimate arterial values during and after a stepdown infusion in healthy adults?
Venous concentrations of propofol do not accurately estimate arterial values during or after a stepdown infusion, indicating arterial sampling is necessary for pharmacokinetic studies.
Arterial propofol levels exceed venous during infusion and reverse after; leaves open sampling-site effects on PK monitoring in clinical practice.
To compare the arterial and venous concentration differences of propofol, six healthy adult patients received a propofol infusion by the Bristol three-stage manual stepdown technique. Both the mean arterial and venous concentrations of propofol remained relatively stable during the 40-min infusion. Simultaneous blood sampling from the artery and vein during the infusion period resulted in arterial concentrations significantly higher than venous concentrations. This relationship was reversed after stopping the infusion. The mean +/- SD (range) venous to arterial concentration differences were -28.8% +/- 18.3% (-71% to 1.7%) during the infusion and 18.9% +/- 13.4% (-1.5% to 40.9%) after the infusion. We conclude that venous concentrations were not useful to estimate the arterial value during and after a stepdown propofol infusion. Arterial sampling is more appropriate in pharmacologic studies of propofol.
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Wang et al. (1994) studied Healthy (n=6). Propofol infusion was evaluated on Venous to arterial concentration differences of propofol. Arterial concentrations of propofol were significantly higher than venous concentrations during a 40-minute infusion (difference -28.8% ± 18.3%), a relationship that reversed after the infusion.
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