Key result
Exercise thallium perfusion defect size predicts 6-month cardiac events in stabilized unstable angina, outperforming Holter monitoring.
Why the study?
The relative value of invasive and noninvasive predictors of outcome after unstable angina was unclear after medical stabilization.
Does quantitative exercise thallium tomography predict cardiac events better than Holter ST-segment monitoring in patients with medically stabilized unstable angina?
Cohort (n=54)
No
Does quantitative exercise thallium tomography predict cardiac events better than Holter ST-segment monitoring in patients with medically stabilized unstable angina?
Quantitative exercise thallium scintigraphy provides greater prognostic value for risk stratification than Holter ST-segment monitoring in patients with medically stabilized unstable angina, particularly those without prior myocardial infarction.
Prior MI history best predicts events after stabilized unstable angina; leaves open whether thallium imaging refines risk stratification beyond clinical variables.
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Marmur et al. (1990) conducted a cohort in unstable angina (n=54). Quantitative exercise thallium tomography vs. Holter ST-segment monitoring was evaluated on cardiac event within 6 months. Quantitative exercise thallium perfusion defect size (17% vs 6%, P=0.05) predicted 6-month cardiac events in medically stabilized unstable angina, whereas Holter ST-segment monitoring did not.
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