Key result
Adrenaline (epinephrine) for out-of-hospital cardiac arrest can restart the heart but is no good for the brain.
RCT
May limit adrenaline in out-of-hospital arrest to prioritize ROSC; leaves open trials of brain-protective alternatives.
The study A randomised trial of epinephrine in out-of-hospital cardiac arrest Perkins GD, Ji C, Deakin CD, Quinn T, Nolan JP, Scomparin C, Regan S, Long J, Slowther A, Pocock H, Black JJM, Moore F, Fothergill RT, Rees N, O’Shea L, Docherty M, Gunson I, Han K, Charlton K, Finn J, Petrou S, Stallard N, Gates S, Lall R for the PARAMEDIC2 Collaborators Published on 18 July 2018 N Engl J Med 2018;379:711-21. This project was funded by the National Institute for Health Research HTA Programme (project number 12/127/126). To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000639/adrenaline-can-restart-the-heart-but-is-no-good-for-the-brain
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Cook et al. (2019) conducted an RCT in out-of-hospital cardiac arrest. epinephrine was evaluated. Adrenaline (epinephrine) for out-of-hospital cardiac arrest can restart the heart but is no good for the brain.
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