Key result
Acetic acid-induced programmed cell death in yeast can occur via alternative pathways, one dependent on cytochrome c release requiring YCA1, and others independent of it.
Population
Yeast cells (wild type, Deltayca1, Deltacyc1,7, and Deltacyc1,7Deltayca1)
Comparison
Acetic acid (AA) to induce programmed cell death vs Comparison between wild type and mutant yeast…
Design
Preclinical
Authors
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Does not inform clinical cardiac apoptosis management; leaves open YCA1-independent PCD mechanisms in mammalian models.
Yeast acetic acid-induced programmed cell death can occur via alternative pathways, one dependent on cytochrome c release requiring YCA1, and others independent of it.
Guaragnella et al. (2009) studied Acetic acid-induced programmed cell death in yeast. Acetic acid vs. Wild type vs mutant yeast strains (Deltayca1, Deltacyc1,7, Deltacyc1,7Deltayca1) was evaluated on AA-PCD occurrence, hydrogen peroxide production, and caspase activity. Acetic acid-induced programmed cell death in yeast can occur via alternative pathways, one dependent on cytochrome c release requiring YCA1, and others independent of it.
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